Endothelin-1 regulates the dorsoventral branchial arch patterning in mice
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منابع مشابه
Endothelin-1 regulates the dorsoventral branchial arch patterning in mice
Endothelin-1 (ET-1), a 21-amino acid peptide secreted by the epithelium and core mesenchyme in the branchial arches as well as vascular endothelium, is involved in craniofacial and cardiovascular development through endothelin receptor type-A (EdnrA) expressed in the neural crest-derived ectomesenchyme. Here we show that ET-1(-/-) mutant mice exhibit a homeotic-like transformation of the lower ...
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Intercellular interactions within the branchial arch (BA) system is essential for craniofacial development. Endothelin-1 (ET-1), produced by the branchial epithelium and core mesenchyme, acts on cranial neural crest-derived ectomesenchymcal cells expressing endothelin A receptor (ETAR) and regulates expression of crucial genes such as Dlx6, a member of distalless homeobox gene family, and its d...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2004
ISSN: 0925-4773
DOI: 10.1016/j.mod.2004.02.002